Year: 2020
Type: review
Abstract: In this review, we discuss gut microbial-derived metabolites involved with the origins and pathophysiology of asthma, a chronic respiratory disease that is influenced by the microbiome. Although both gut and airway microbiomes may be important in asthma development, we focus here on the gut microbiome and metabolomic pathways involved in immune system ontogeny. Metabolite classes with existing evidence that microbial-derived products influence asthma risk include short chain fatty acids, polyunsaturated fatty acids and bile acids. While tryptophan metabolites and sphingolipids have known associations with asthma, additional research is needed to clarify the extent to which the microbiome contributes to the effects of these metabolites on asthma. These metabolite classes can influence immune function in one of two ways: (i) promoting growth or maturity of certain immune cell populations or (ii) influencing antigenic load by enhancing the number or species of specific bacteria. A more comprehensive understanding of how gut microbes and metabolites interact to modify asthma risk and morbidity will pave the way for targeted diagnostics and treatments.
Source: Metabolites
Language: English
Topic: Gut microbiota and health
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $1,690
Awards: Multi-omic approaches to mechanisms of vitamin D, environmental influences, and the microbiome on asthma, Mechanistic insights into asthma pathogenesis through the integration of asthma genes, risk exposures, and metabolomics, Integrative Metabolomics of Asthma Severity, Multi-Omics Analysis of the Association of Polyunsaturated Fatty Acids with Asthma and Allergy in Childhood, Multi-Omic Endotyping of Asthma, Environmental Agents as Modulators of Disease Processes
OpenAlex ID: W3009657488