Work

Molecular Mechanisms Linking Oxidative Stress and Diabetes Mellitus

Year: 2020

Type: review

Abstract: Type 2 diabetes mellitus (T2DM) is the most prevalent metabolic disorder characterized by chronic hyperglycemia and an inadequate response to circulatory insulin by peripheral tissues resulting in insulin resistance. Insulin resistance has a complex pathophysiology, and it is contributed to by multiple factors including oxidative stress. Oxidative stress refers to an imbalance between free radical production and the antioxidant system leading to a reduction of peripheral insulin sensitivity and contributing to the development of T2DM via several molecular mechanisms. In this review, we present the molecular mechanisms by which the oxidative milieu contributes to the pathophysiology of insulin resistance and diabetes mellitus.

Source: Oxidative Medicine and Cellular Longevity

DOI: 10.1155/2020/8609213

Authors: Habib Yaribeygi, Thozhukat Sathyapalan, Stephen L. Atkin, Amirhossein Sahebkar

Institutions: Semnan University of Medical Sciences, University of Hull, Hull York Medical School, Weill Cornell Medical College in Qatar, Mashhad University of Medical Sciences

Language: English

Topic: Antioxidant Activity and Oxidative Stress

Subfield: Biochemistry (medical)

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $2,680