Work

Mechanochemical enzymes and protein machines as hydrodynamic force dipoles: the active dimer model

Year: 2020

Type: article

Abstract: Mechanochemically active enzymes change their shapes within every turnover cycle. Therefore, they induce circulating flows in the solvent around them and behave as oscillating hydrodynamic force dipoles. Because of non-equilibrium fluctuating flows collectively generated by the enzymes, mixing in the solution and diffusion of passive particles within it are expected to get enhanced. Here, we investigate the intensity and statistical properties of such force dipoles in the minimal active dimer model of a mechanochemical enzyme. In the framework of this model, novel estimates for hydrodynamic collective effects in solution and in lipid bilayers under rapid rotational diffusion are derived, and available experimental and computational data is examined.

Source: Soft Matter

DOI: 10.1039/d0sm01138j

Authors: Yuto Hosaka, Shigeyuki Komura, Alexander S. Mikhailov

Institutions: Tokyo Metropolitan University, Kanazawa University, Fritz Haber Institute of the Max Planck Society, Nano Life Science Institute, Kanazawa University

Language: English

Topic: Micro and Nano Robotics

Subfield: Condensed Matter Physics

Field: Physics and Astronomy

Domain: Physical Sciences

Open Access status: hybrid

Funders: Ministry of Education, Culture, Sports, Science and Technology, Max-Planck-Gesellschaft, Japan Society for the Promotion of Science

Awards: G2973521497, G7037641111, 生体分子マシンが誘起する細胞内レオロジー応答の理論研究, Enzymes as Active Matter at Nanoscales, Nonequilibrium dynamics of micromachines in soft matter