Work

Encoding, Consolidation, and Renormalization in Depression: Synaptic Homeostasis, Plasticity, and Sleep Integrate Rapid Antidepressant Effects

Year: 2020

Type: article

Abstract: Recent studies have strived to find an association between rapid antidepressant effects and a specific subset of pharmacological targets and molecular pathways.Here, we propose a broader hypothesis of encoding, consolidation, and renormalization in depression (ENCORE-D), which suggests that, fundamentally, rapid and sustained antidepressant effects rely on intrinsic homeostatic mechanisms evoked as a response to the acute pharmacological or physiologic effects triggered by the treatment.We review evidence that supports the notion that various treatments with a rapid onset of action, such as ketamine, electroconvulsive therapy, and sleep deprivation, share the ability to acutely excite cortical networks, which increases synaptic potentiation, alters patterns of functional connectivity, and ameliorates depressive symptoms.We proceed to examine how the initial effects are short-lived and, as such, require both consolidation

Source: Pharmacological Reviews

DOI: 10.1124/pr.119.018697

Authors: Tomi Rantamäki, Samuel Kohtala

Institution: University of Helsinki

Language: English

Topic: Treatment of Major Depression

Subfield: Pharmacology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,500