Work

Skeletal Muscle Mitochondrial Alterations in Carboxyl Terminus of Hsc70 Interacting Protein (chip) -/- Mice.

Year: 2016

Type: article

Abstract: AIM: mutations. However, mechanisms responsible for these deficits are not known. METHODS: In a survey of skeletal muscle by transmission electron microscopy. RESULTS: CHIP-/- mice at 6 months of age were found to have morphological changes consistent with increased sarcoplasmic reticulum compartments in quadriceps muscle and gastrocnemius (toxic oligomers and tubular aggregates), but not in soleus. CONCLUSION: Since CHIP has been implicated in ER stress in non-muscle cells, these findings illustrate potential parallel roles of CHIP in the muscle sarcoplasmic reticulum, a hypothesis that may be clinically relevant in a variety of common muscular and cardiac diseases.

Source: PubMed

Authors: Jonathan C Schisler, Cam Patterson, Monte S Willis

Institutions: University of North Carolina at Chapel Hill, NewYork–Presbyterian Hospital, Weill Cornell Medical Center

Language: English

Topic: Muscle Physiology and Disorders

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Institutes of Health

Awards: Myocyte specific regulation of metabolism and the response to biomechanical force, CHIP: A link between the chaperone and proteasome system, Myocyte Signaling and the Response to Stress