Year: 2020
Type: article
Abstract: Cholestatic liver diseases refer to a diverse group of disorders that disrupt bile flow. They occur secondary to diminished bile acid secretion by hepatocytes, or impaired transport through the biliary system. The resulting accumulation of bile acids has previously been shown to initiate liver injury by inducing expression of inflammatory genes and cytokines in hepatocytes.1,2 However, it is unclear what mediates the downstream inflammatory response. In this issue of Cellular and Molecular Gastroenterology and Hepatology, Cai et al3 demonstrate that the inflammasome, a danger-sensing cytosolic multiprotein complex, is involved in the pathogenesis of cholestatic liver injury.
Authors: Xiao Zhao, Kirk J. Wangensteen
Institutions: Columbia University, University of Pennsylvania
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,000
OpenAlex ID: W3010125560