Work

Ecological and individual data both indicate that influenza inhibits rhinovirus infection

Year: 2020

Type: letter

Abstract: We read the article “Virus–virus interactions impact the population dynamics of influenza and the common cold” by Nickbakhsh et al. (1) with great interest. The authors analyzed a large Scottish dataset consisting of virology results from patients with acute respiratory illnesses and used mathematical models to identify a negative interaction between influenza and rhinovirus (RV) infection. Furthermore, they performed epidemiologic simulations demonstrating that influenza-mediated induction of a refractory period could account for the significant reduction in RV illness prevalence. In fact, we demonstrated that influenza can induce a refractory period using individual-level data obtained from a cohort of children that … [↵][1]1To whom correspondence may be addressed. Email: kloepfer{at}iu.edu. [1]: #xref-corresp-1-1

Source: Proceedings of the National Academy of Sciences

DOI: 10.1073/pnas.1922920117

Authors: Kirsten M. Kloepfer, James E. Gern

Institutions: Indiana University Indianapolis, Indiana University School of Medicine, Indiana University – Purdue University Indianapolis, University of Wisconsin–Madison

Language: English

Topic: Respiratory viral infections research

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Medical Research Council, Biotechnology and Biological Sciences Research Council, National Institute of Allergy and Infectious Diseases