Current and Future Outlook on Disease Modification and Defining Low Disease Activity in Systemic Sclerosis
Year: 2020
Type: article
Abstract: Systemic sclerosis (SSc) is an autoimmune rheumatic disease with heterogeneous clinical manifestations and a variable course in which the severity of the pathology dictates the disease prognosis and course. Among autoimmune rheumatic diseases, SSc has the highest mortality rate among all rheumatic diseases, though there are exciting new therapeutic targets that appear to halt the progression of SSc manifestations such as skin or lung fibrosis. In selected patients, high-intensity regimens with autologous stem cell transplantation can favorably modify the course. In what was once thought to be an untreatable disease, targeted therapies have now changed the outlook of SSc to a treatable disorder. Herein, we discuss the targeted therapies modifying the outlook on selected organ involvement and creating opportunities for future treatment. We also present a framework for defining low disease activity in SSc.
Source: Arthritis & Rheumatology
DOI: 10.1002/art.41246
Institutions: University of Michigan, University of Florence, University of California, Los Angeles, University of Washington, Nippon Medical School, Inserm, Sorbonne Paris Cité, Hôpital Cochin, Université Paris Descartes, The Royal Free Hospital, University College London, Royal National Hospital for Rheumatic Diseases, Royal United Hospital, Dartmouth College, Dartmouth Health
Language: English
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W3010510320