Work

PBRM1 suppresses tumor growth as a novel p53 acetylation reader

Year: 2020

Type: article

Abstract: The reader(s) for acetylated tumor antigen p53 remains elusive. Here, PBRM1 (polybromo-1) is identified as a reader for acetylated lysine382 on p53 through its bromodomain 4 (BD4). PBRM1 BD4 mutants fail to support p53 transcriptional activity and suppress tumor growth. Thus PBRM1 suppresses tumor growth through p53 in kidney cancer.

Source: Molecular & Cellular Oncology

DOI: 10.1080/23723556.2020.1729680

Authors: Weijia Cai, Liya Su, Haifeng Yang

Institution: Thomas Jefferson University

Language: English

Topic: Cancer-related Molecular Pathways

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

Open Access status: hybrid

Estimated APC paid: $1,590

Funder: National Cancer Institute