Work

Noncatalytic Bruton's tyrosine kinase activates PLCγ2 variants mediating ibrutinib resistance in human chronic lymphocytic leukemia cells

Year: 2020

Type: article

Abstract: Because catalytically-inactive BTK is insensitive to active-site BTK inhibitors, the mechanism involving the noncatalytic BTK uncovered here may contribute to preexisting reduced sensitivity or even primary resistance of CLL to these drugs.

Source: Journal of Biological Chemistry

DOI: 10.1074/jbc.ra119.011946

Authors: Martin Wist, Laura Meier, Orit Gutman, Jennifer Haas, Sascha Endres, Yuan Zhou, Reinhild Rösler, Sebastian Wiese, Stephan Stilgenbauer, Elias Hobeika, Yoav I. Henis, Peter Gierschik, Claudia Walliser

Institutions: Universität Ulm, Tel Aviv University, University Hospital Ulm

Language: English

Topic: Chronic Lymphocytic Leukemia Research

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,430

Funders: Deutsche Forschungsgemeinschaft, Ministerium für Wissenschaft, Forschung und Kunst Baden-Württemberg

Awards: G3984152089, G5968707537

OpenAlex ID: W3011102184

FWCI: 3.666

Cites: 108

Cited by: 35

Related to: 10