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Rational Design of New Dihydrobenzooxophosphole-Based Lewis Base Organocatalysts

Year: 2020
Type: article
Abstract: A series of new dihydrobenzooxophosphole-based Lewis base organocatalysts were designed and synthesized. They are shown to be effective in trichlorosilane-mediated stereoselective conjugate reductions of C=C bonds. DFT calculations reveal that the strong hydrogen bonds between the amide linker and the chloride on silicon in the transition state contribute to the high reactivity of the catalyst.
Source: Synlett
DOI: 10.1055/s-0039-1690851
Authors: Bo Qu, Lalith P. Samankumara, Anjan Saha, Mac G. Schumer, Zhengxu S. Han, Nizar Haddad, Carl A. Busacca, Nathan K. Yee, Marisa C. Kozlowski, Jinghua J. Song, Chris H. Senanayake
Language: English
Field: Chemistry
Open Access status: green
OpenAlex ID: W3011195181
FWCI: 0.158
Cites: 19
Cited by: 5
Related to: 10