Replication of FTO Gene associated with lean mass in a Meta-Analysis of Genome-Wide Association Studies
Year: 2020
Type: review
Study design: Observational Study
Abstract: Sarcopenia is characterized by low skeletal muscle, a complex trait with high heritability. With the dramatically increasing prevalence of obesity, obesity and sarcopenia occur simultaneously, a condition known as sarcopenic obesity. Fat mass and obesity-associated (FTO) gene is a candidate gene of obesity. To identify associations between lean mass and FTO gene, we performed a genome-wide association study (GWAS) of lean mass index (LMI) in 2207 unrelated Caucasian subjects and replicated major findings in two replication samples including 6,004 unrelated Caucasian and 38,292 unrelated Caucasian. We found 29 single nucleotide polymorphisms (SNPs) in FTO significantly associated with sarcopenia (combined p-values ranging from 5.92 × 10−12 to 1.69 × 10−9). Potential biological functions of SNPs were analyzed by HaploReg v4.1, RegulomeDB, GTEx, IMPC and STRING. Our results provide suggestive evidence that FTO gene is associated with lean mass.
Source: Scientific Reports
Authors: Shu Ran, Zi-Xuan Jiang, Xiao He, Yu Liu, Yu-Xue Zhang, Lei Zhang, Yu-Fang Pei, Meng Zhang, Rong Hai, Gui-Shan Gu, Bao-Lin Liu, Qing Tian, Yong-Hong Zhang, Jing-Yu Wang, Hong-Wen Deng
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $1,870
Funders: National Natural Science Foundation of China, Government of Jiangsu Province, Natural Science Foundation of Jiangsu Province, University of Shanghai for Science and Technology, National Institutes of Health, Shanghai Leading Academic Discipline Project, National Institute on Aging, National Heart, Lung, and Blood Institute, Fogarty International Center, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institute of Dental and Craniofacial Research, Office of Research on Women's Health
Awards: G1287431292, G1344639305, G1490530680, G2290742579, G250621538, G2559736970, G3306961714, G3342643523, Genomic Convergence for Female Osteoporosis Risk Genes, Genomic search for bone mass QTLs, G3667269547, G36937976, Decoding Methylation Mediated Epigenomic Contributions to Male Osteoporosis, Genome-wide association study of periodontitis, G5125401475, Robust and Powerful Test of Candidate Genes to Bone Mass, G5164707915, G5441102360, G5571998519, Genetics of Osteoporotic Fractures in Chinese, The Framingham Heart Study, SNP HEALTH ASSOCIATION RESOURCE (SHARE), G7275880125, G80800813, Identification of Proteins Important for Male Osteoporosis, G8729224144, G9000050004, G9000124674, Novel Molecular Biomarkers of Bone Microarchitecture, Trans-omics Integration of Multi-omics Studies for Osteoporosis, G936600500
OpenAlex ID: W3011367933