Year: 2020
Type: article
Study design: Case Report
Abstract: Antibiotic resistance is on the rise, leading to an increase in morbidity and mortality due to infectious diseases. Klebsiella pneumoniae is a Gram-negative bacterium that causes bronchopneumonia, abscesses, urinary tract infection, osteomyelitis, and a wide variety of infections. The ubiquity of this microorganism confounds with the great increase in antibiotic resistance and have bred great concern worldwide. K. pneumoniae sequence type (ST) 307 is a widespread emerging clone associated with hospital-acquired infections, although sporadic community infections have also been reported. The aim of our study is to describe the first case of Klebsiella pneumoniae (ST) 307 harboring the blaOXA-48-like gene in Ecuador. We characterized a new plasmid that carry OXA-48 and could be the source of future outbreaks. The strain was recovered from a patient with cancer previously admitted in a Ukrainian hospital, suggesting that this mechanism of resistance could be imported. These findings highlight the importance of programs based on active molecular surveillance for the intercontinental spread of multidrug-resistant microorganisms with emergent carbapenemases.
Source: Microorganisms
Institutions: Pontificia Universidad Católica del Ecuador, Instituto Nacional de Investigación en Salud Pública, Central University of Ecuador, Universidad Autónoma del Estado de Morelos, Hospital de Especialidades Eugenio Espejo, Ministerio de Salud Pública, Universidad San Francisco de Quito, Administración Nacional de Laboratorios e Institutos de Salud, World Health Organization Regional Office for the Americas, Louisiana State University, Louisiana State University Health Sciences Center Shreveport
Language: English
Subfield: Molecular Medicine
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $1,690
OpenAlex ID: W3011538752