Morin, a plant derived flavonoid, modulates the expression of peroxisome proliferator-activated receptor-γ coactivator-1α mediated by AMPK pathway in hepatic stellate cells.
Year: 2017
Type: article
Abstract: conditions and to attempt to investigate the involved potential mechanisms by western blotting, RT-PCR, and transfection assays. The results revealed that morin increased the expression of PGC-1α and the effects of morin on the expression of PGC-1α were positively associated with the stimulation of adenosine monophosphate-activated protein kinase (AMPK). Additionally, morin enhanced superoxide dimutase-2 (SOD-2) transcript levels as well as the activity via AMPK/PGC-1α axis. Furthermore, PGC-1α was found to suppress α1 (I) collagen transcript levels in HSCs. Taken together, these results revealed that the effect of morin on the enhancement of the expression of PGC-1α is mediated through AMPK pathway which ultimately leads to increase in the activity of PPARγ and SOD-2.
Source: PubMed Central
Authors: Wei Yuan, Shoaib Ahmad, Ajaz Najar
Language: English
Subfield: Pharmacology (medical)
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W3011737578