Work

CircRNA circFNDC3B promotes esophageal cancer progression via cell proliferation, apoptosis, and migration regulation.

Year: 2018

Type: article

Abstract: BACKGROUND: Esophageal cancer is one of the most common malignant tumors threatening human health worldwide. Circular RNAs (circRNAs) are a large group of covalently closed continuous loops that are prevalently expressed in human cells and might be applied as novel esophageal cancer biomarkers. PURPOSE: , in esophageal cancer, as well as determine its function in the regulation of esophageal cell proliferation, apoptosis, migration, and invasion. METHODS: expression by gene silencing were subjected to proliferation analysis with the MTS method, FITC Annexin V apoptosis detection, and a proliferation and invasion evaluation using a transwell system. RESULTS: expression by gene silencing showed inhibited proliferation, increased apoptosis, and weakened migration and invasion abilities. CONCLUSION: encoded by two FNDC3B gene exons is an important regulator of esophageal cancer progression.

Source: PubMed

Authors: Gang Luo, Ruifeng Li, Zijun Li

Institutions: Guangdong General Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou Medical University

Language: English

Topic: Circular RNAs in diseases

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W3011798161

FWCI: 0.546

Cites: 25

Cited by: 28

Related to: 10