Cancer Survivorship and Subclinical Myocardial Damage

Year: 2019

Type: article

Abstract: Cancer survivors might have an excess risk of cardiovascular disease (CVD) resulting from toxicities of cancer therapies and a high burden of CVD risk factors. We sought to evaluate the association of cancer survivorship with subclinical myocardial damage, as assessed by elevated high-sensitivity cardiac troponin T (hs-cTnT) test results. We included 3,512 participants of the Atherosclerosis Risk in Communities Study who attended visit 5 (2011-2013) and were free of CVD (coronary heart disease, heart failure, or stroke). We used multivariate logistic regression to evaluate the cross-sectional associations of survivorship from any, non-sex-related, and sex-related cancers (e.g., breast, prostate) with elevated hs-cTnT (≥14 ng/L). Of 3,512 participants (mean age, 76 years; 62% women; 21% black), 19% were cancer survivors. Cancer survivors had significantly higher odds of elevated hs-cTnT (OR = 1.26, 95% CI: 1.03, 1.53). Results were similar for survivors of non-sex-related and colorectal cancers, but there was no association between survivorship from breast and prostate cancers and elevated hs-cTnT. Results were similar after additional adjustments for CVD risk factors. Survivors of some cancers might be more likely to have elevated hs-cTnT than persons without prior cancer. The excess burden of subclinical myocardial damage in this population might not be fully explained by traditional CVD risk factors.

Source: American Journal of Epidemiology

DOI: 10.1093/aje/kwz088

Authors: Roberta Florido, Alexandra K Lee, John W McEvoy, Ron C Hoogeveen, Silvia Koton, Mara Z Vitolins, Chetan Shenoy, Stuart D Russell, Roger S Blumenthal, Chiadi E Ndumele, Christie M Ballantyne, Corinne E Joshu, Elizabeth A Platz, Elizabeth Selvin

Institutions: Johns Hopkins University, Baylor College of Medicine, Tel Aviv University, Wake Forest University Health Sciences, Wake Forest University, University of Minnesota, Duke University, Sidney Kimmel Comprehensive Cancer Center

Language: English

Topic: Chemotherapy-induced cardiotoxicity and mitigation

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Heart, Lung, and Blood Institute, National Cancer Institute, National Institute of Diabetes and Digestive and Kidney Diseases

OpenAlex ID: W3011834804