Targeting Acetyl-CoA Metabolism in Bacteria - Structural Characterization of Pantothenate Kinases and Lipoate-Protein Ligases
Year: 2017
Type: dissertation
Abstract: Antibiotics are regarded as one of the most important medical discoveries of all time. Since their clinical implementation in the early 20th century, countless lives have been saved, rates of infectious disease have plummeted, and medical advancements such as surgical implantation have flourished. However, the rise of antibiotic resistance has mirrored the rise in antibiotic use, and we are now running out of reliable drugs. At a time when there is a negative correlation between the rise of resistance and the approval of new drugs, the future of antibiotic development needs to embrace novel treatment strategies and target pathways to help turn the tide in the arms race against bacterial drug resistance. In the present study, we propose the central axis between coenzyme A (CoA) biosynthesis and acetyl-CoA (AcCoA) production to be a viable target for future antimicrobial development. AcCoA and CoA are central to pyruvate oxidation, the TCA cycle, biofilm
Source: TSpace (University of Toronto)
Author: Scott J. Hughes
Language: English
Subfield: Structural Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W3012150334