Work

miR-26b inhibits total neurite outgrowth, promotes cells apoptosis and downregulates neprilysin in Alzheimer's disease.

Year: 2018

Type: article

Abstract: <0.05). In addition, neprilysin (NEP) protein and mRNA expressions were decreased in miR-26b mimic group than NC1-mimic group and was increased in miR-26b inhibitor group than NC2-inhibitor group. However, protein or mRNA expression of EIF2S1 and αTTP was not affected by miR-26b. In conclusion, miR-26b inhibits neurite outgrowth, induces cells apoptosis and downregulates NEP expression in PC12 cellular AD model.

Source: Europe PMC (PubMed Central)

Authors: Tingting Chu, Yongwei Shu, Yang Qu, Shasha Gao, Liming Zhang

Institutions: Fourth Affiliated Hospital of Harbin Medical University, First Affiliated Hospital of Harbin Medical University, Peking Union Medical College Hospital

Language: English

Topic: Alzheimer's disease research and treatments

Subfield: Cellular and Molecular Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W3012171566

FWCI: 0.489

Cites: 28

Cited by: 18

Related to: 10