In Vivo Imaging of Venous Thrombus and Pulmonary Embolism Using Novel Murine Venous Thromboembolism Model
Year: 2020
Type: article
Abstract: This work established a new murine venous thromboembolism (VTE) model. This model has multiple novel features representing clinical VTE that include the following: 1) deep venous thrombosis (DVT) was formed and extended in the long axis of femoral/saphenous vein; 2) thrombus was formed in a venous valve pocket; 3) deligation of suture-induced spontaneous pulmonary emboli of fibrin-rich DVT; and 4) cardiac motion-free femoral/saphenous vein allowed high-resolution intravital microscopic imaging of fibrin-rich DVT. This new model requires only commercially available epifluorescence microscopy. Therefore, this model has significant potential for better understanding of VTE pathophysiology.
Institutions: Kobe University, Massachusetts General Hospital
Language: English
Subfield: Internal Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,400
Funders: Boston Scientific Corporation, Sysmex Corporation, Ministry of Education, Culture, Sports, Science and Technology, Mochida Memorial Foundation for Medical and Pharmaceutical Research, Lotte Foundation, National Institutes of Health, Abbott Vascular, Japan Society for the Promotion of Science, National Heart, Lung, and Blood Institute
OpenAlex ID: W3012225876