Expression of FANCD2 is associated with prognosis in patients with nasopharyngeal carcinoma.
Year: 2019
Type: article
Study design: Observational Study
Abstract: , stage III-IV NPC tissues with a duration of disease longer than 6 months. Moreover, compared with patients with cervical lymph node metastases, FANCD2 was elevated in tissues from patients without cervical lymph node metastases. Furthermore, the NPC patients in the high-FANCD2-expression group exhibited a higher recurrence rate than the patients in the low-FANCD2-expression group. Finally, the disease-free survival rate of the high-expression group was significantly lower than it was in the low-expression group. Therefore, FANCD2 is associated with the occurrence, differentiation, and cervical lymph node metastasis of NPC. With the development of NPC, FANCD2 is down-regulated. FANCD2 may be a molecular marker for the early diagnosis and prognosis of NPC.
Source: PubMed
Authors: Shengen Xu, Feipeng Zhao, Zhuoping Liang, Huajun Feng, Yilin Bao, Wei Xu, Chong Zhao, Gang Qin
Language: English
Topic: Head and Neck Cancer Studies
Subfield: Otorhinolaryngology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W3012368465