Minimally invasive and volume-metered extraction of interstitial fluid:bloodless point-of-care sampling for bioanalyte detection
Year: 2020
Type: article
Abstract: Sampling of biological fluids is fundamental in health monitoring and, currently, blood analysisis the standard practice. However, blood sampling entails a series of drawbacks including pain,discomfort, and risk of infections. Interstitial fluid, having a good correlation with blood concentrationdynamics for several analytes, is a promising alternative monitoring matrix because it can be sampled ina minimally invasively manner from the skin, without the need for the more invasive and painfulextraction methods used for blood. Currently, there are no simple devices available to sample and storeknown amounts of interstitial fluid. In this work, a painless microneedle-based sampling device designedto extract 1 μL of fluid from the dermis was realized. The sampled liquid is metered and stored in a papermatrix embedded in a microfluidic chip. The sample can then be analyzed using state-of-the-art tools,such as mass spectrometry (LC-MS/MS).
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: green
OpenAlex ID: W3012373358