Work

Crystallisation From Volatile Deep Eutectic Solvents

Year: 2019

Type: article

Abstract: A new class of deep eutectic solvents are presented where one component of the system is inherently volatile, enabling a premeditated, auto-destructive capability which leads inexorably to a series of novel crystal structures. These volatile deep eutectic solvents are easily-formed liquids with a greatly depressed melting point and exhibit all of the physical characteristics of classical deep eutectic solvents, with the exception that the hydrogen-bond donor component is volatile when exposed to the atmosphere at room temperature. We demonstrate the effectiveness of this concept through the exquisite control of pharmaceutical polymorphism, among which is a more efficacious form of acetaminophen, which can be formed spontaneously for the first time at room temperature.

Source: Bristol Research (University of Bristol)

DOI: 10.48550/arxiv.1902.08376

Authors: Potticary, Jason, Hall, Charlie, Hamilton, Victoria, McCabe, James F., Hall, Simon R.

Institutions: University of Bristol, AstraZeneca (United Kingdom)

Language: English

Topic: Ionic liquids properties and applications

Subfield: Catalysis

Field: Chemical Engineering

Domain: Physical Sciences

Open Access status: green

Funders: European Commission, Engineering and Physical Sciences Research Council

Awards: G4897964007, EPSRC Centre for Doctoral Training in Condensed Matter Physics, EPSRC Centre for Doctoral Training in Functional Materials: The BCFN, Magnetic Control of Polymorphism in Pharmaceutical Compounds