Year: 2012
Type: article
Abstract: Monocytes serve as a central defense system against infection and injury but can also promote pathological inflammatory responses. Considering the evidence that monocytes exist in at least two subsets committed to divergent functions, we investigated whether distinct factors regulate the balance between monocyte subset responses in vivo. We identified a microRNA (miRNA), miR-146a, which is differentially regulated both in mouse (Ly-6C(hi)/Ly-6C(lo)) and human (CD14(hi)/CD14(lo)CD16(+)) monocyte subsets. The single miRNA controlled the amplitude of the Ly-6C(hi) monocyte response during inflammatory challenge whereas it did not affect Ly-6C(lo) cells. miR-146a-mediated regulation was cell-intrinsic and depended on Relb, a member of the noncanonical NF-κB/Rel family, which we identified as a direct miR-146a target. These observations not only provide mechanistic insights into the molecular events that regulate responses mediated by committed monocyte precursor populations but also identify targets for manipulating Ly-6C(hi) monocyte responses while sparing Ly-6Clo monocyte activity.
Source: Cell Reports
Institutions: Harvard University, Massachusetts General Hospital, Center for Systems Biology, California Institute of Technology, Center for Computational and Integrative Biology, Massachusetts General Hospital, Ludwig Cancer Research, Cancer Center Amsterdam, Amsterdam UMC Location Vrije Universiteit Amsterdam, King's College London, École Polytechnique Fédérale de Lausanne
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $5,620
Awards: Imaging and Treating Inflammation in Stroke by Targeting Myeloperoxidase, Myeloperoxidase, imaging biomarker and treatment target for multiple sclerosis, In vivo behavior of monocytes in resting and inflammatory conditions, Center for the Study of Inflammatory Bowel Disease at Massachusetts General Hospital
OpenAlex ID: W2151622392