Differential Transcriptomic and Proteomic Analysis between Embryonic Cells and Aged Cells Confirms that Embryo is a Plethora of Rejuvenating Molecules
Year: 2019
Type: article
Abstract: Regenerative medicine has a wide scope, started with direct transplantation of various stems cells into the tissues or
organs for functional restoration. In a further development, molecules of Stem cells are used for the treatment of
organ function restoration, but they are the source for a few tissue growth factors. As they have limited scope, there is
a need for comprehensive methods in treating age-related organ function restoration.
Sexually reproducing organisms pass through the different stage at which it starts their life from zygote to till it
becomes a complete organism. Tissue differentiation and organogenesis are not life-long processes; they occur only at
the embryonic stage that follows specific gene signatures. Every organ and tissues are unique in their functions; they
need specific gene expressions and their proteins for differentiation and development.
Recent studies of comparative transcriptomic analysis of adult human Mesenchymal Stem Cells (MSCs) derived from
dental pulp and adipose tissues showed that dental pulp-derived MSCs exhibit gene expression signatures of neuronal
growth while adipose tissue-derived MSCs exhibit signatures of angiogenesis and hair growth. This confirms that
Stem cells are a limited source for growth factors
This review emphasizes the transcriptomic and proteomic comparison between aged tissue cells and embryonic tissue
cells. This comparative compositional analysis is a fruitful approach for tracing rejuvenating or anti-aging and growth
factor for the whole organism.
Language: English
Subfield: Cell Biology
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W3012675566