Long non-coding RNA PANDAR overexpression serves as a poor prognostic biomarker in oral squamous cell carcinoma.
Year: 2018
Type: article
Study design: Observational Study
Abstract: BACKGROUND: Long non-coding RNA (lncRNA) has been found to play a crucial role in carcinogenesis and in evaluating prognosis of multiple neoplasms. PANDAR (promoter of CDKN1A antisense DNA damage activated RNA), a newly discovered cancer-associated RNA is abnormally expressed in a wide variety of tumors. Expression and the functional role of PANDAR in human oral squamous cell carcinoma (OSCC), however, needs to be completely elucidated. METHODS: . RESULTS: PANDAR was highly expressed in OSCC tissues and cell lines (P < 0.05) and its high expression level was found to be closely associated with advanced TNM stage (P = 0.004) and positive distant metastasis (P = 0.001). Furthermore, overall survival rate of OSCC patients with high PANDAR expression was poorer than patients with low PANDAR expression (P < 0.001). Cox proportional hazards model analysis showed that expression level of PANDAR can be used as an independent prognostic indicator for OSCC. Functionally, knockdown of PANDAR can inhibit proliferation, invasion, and migration of OSCC cells. CONCLUSIONS: Our findings indicate that PANDAR may serve as a promising prognostic biomarker and a new molecular target for new therapies for OSCC patients.
Source: Europe PMC (PubMed Central)
Authors: Zhen Huang, Ting Sang, Ying Zheng, Jun Wu
Institution: Nanchang University
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W3012702693