Work

Potent and broad anticancer activities of leaf extracts from Melia azedarach L. of the subtropical Okinawa islands.

Year: 2020

Type: article

Abstract: . We also performed a preclinical evaluation of MLE treatment on dogs with various cancers in veterinary hospitals. Dogs with various types of cancers showed a mean recovery of 76% when treated with MLE. Finally, we tried to identify the active substances present in MLE. All the active fractions obtained by reverse-phase chromatography contained azedarachin B-related moieties, such as 3-deacetyl-12-hydroxy-amoorastatin, 12-hydroxy-amoorastatin, and 12-hydroxyamoorastaton. In conclusion, MLE contains substances with promising anticancer effects, suggesting their future use as safe and effective anticancer agents.

Source: PubMed

Authors: Kuniaki Nerome, Taku Ito-Kureha, Tiziana Paganini, Takao Fukuda, Yasuhiro Igarashi, Hiroto Ashitomi, Shinya Ikematsu, Tadashi Yamamoto

Institutions: Okinawa Institute of Science and Technology Graduate University, Toyama Prefectural University, National Institute of Technology Okinawa College

Language: English

Topic: Phytochemical compounds biological activities

Subfield: Drug Discovery

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W3012798807

FWCI: 0.251

Cites: 46

Cited by: 7

Related to: 10