Work

Research Models for Studying Vascular Calcification

Year: 2020

Type: article

Abstract: Calcification of the vessel wall contributes to high cardiovascular morbidity and mortality. Vascular calcification (VC) is a systemic disease with multifaceted contributing and inhibiting factors in an actively regulated process. The exact underlying mechanisms are not fully elucidated and reliable treatment options are lacking. Due to the complex pathophysiology, various research models exist evaluating different aspects of VC. This review aims to give an overview of the cell and animal models used so far to study the molecular processes of VC. Here, in vitro cell culture models of different origins, ex vivo settings using aortic tissue and various in vivo disease-induced animal models are summarized. They reflect different aspects and depict the (patho)physiologic mechanisms within the VC process.

Source: International Journal of Molecular Sciences

DOI: 10.3390/ijms21062204

Authors: Jaqueline Herrmann, Milen Babic, Markus Tölle, Markus van der Giet, Mirjam Schuchardt

Institutions: Freie Universität Berlin, Charité - Universitätsmedizin Berlin

Language: English

Topic: Dermatological and Skeletal Disorders

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,819