Year: 2020
Type: article
Abstract: The dynamical properties of cortico-basal ganglia (CBG) circuits are dramatically altered following the loss of dopamine in Parkinson's disease (PD). The neural circuit dysfunctions associated with PD include spike-rate alteration concomitant with excessive oscillatory spike-synchronization in the beta frequency range (12-30 Hz). Which neuronal circuits orchestrate and propagate these abnormal neural dynamics in CBG remains unknown. In this work, we combine in vivo electrophysiological recordings with advanced optogenetic manipulations in normal and 6-OHDA rats to shed light on the mechanistic principle underlying circuit dysfunction in PD. Our results show that abnormal neural dynamics present in a rat model of PD do not rely on cortical or subthalamic nucleus activity but critically dependent on globus pallidus (GP) integrity. Our findings highlight the pivotal role played by the GP which operates as a hub nucleus capable of orchestrating firing rate and synchronization changes across CBG circuits both in normal and pathological conditions.
Source: Nature Communications
Language: English
Subfield: Neurology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $5,380
Awards: G2099415532, Neuronal diversity in globus pallidus: from molecular profiling to function in voluntary movement, G2780345700, G2783095691, G3693981238, Electrophysiological mapping of networks dynamics in basal ganglia in normal and Parkinsonian conditions using optogenetic control of specific neuronal pathway., Bordeaux Region Aquitaine Initiative for Neuroscience, Initiative d’excellence de l’Université de Bordeaux, G7240651115, G7376787254
OpenAlex ID: W3013063797