Work

Cisplatin-Based Chemotherapy of Human Cancers.

Year: 2019

Type: article

Abstract: NER (nuclear excision repair system) by halting cisplatin-induced cell death by activation of ATM (ataxia telangiectasia mutated) pathway. Although treatment has been shown to be effective, many patients experience relapse due to drug resistance. As a result, other platinum compounds such as oxaliplatin and carboplatin have since been used and have shown some levels of effectiveness. In this review, the clinical applications of cisplatin are discussed with a special emphasis on its use in cancer chemotherapy.

Source: PubMed

Authors: Andrea Brown, Sanjay Kumar, Paul B Tchounwou

Institutions: National Institute on Minority Health and Health Disparities, Jackson State University

Language: English

Topic: Metal complexes synthesis and properties

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Institute on Minority Health and Health Disparities

Award: RCMI-Center for Environmental Health