Year: 2020
Type: article
Abstract: Little is known about the potential population-level impact of HIV pre-exposure prophylaxis (PrEP) use among cisgender male sex workers (MSWs), a high-risk subset of cisgender men who have sex with men (MSM). Using an agent-based model, we simulated HIV transmission among cisgender MSM in Rhode Island to determine the impacts of PrEP implementation where cisgender MSWs were equally ("standard expansion") or five times as likely ("focused expansion") to initiate PrEP compared to other cisgender MSM. Without PrEP, the model predicted 920 new HIV infections over a decade, or an average incidence of 0.39 per 100 person-years. In a focused expansion scenario where 15% of at-risk cisgender MSM used PrEP, the total number of new HIV infections was reduced by 58.1% at a cost of $57,180 per quality-adjusted life-year (QALY) gained. Focused expansion of PrEP use among cisgender MSWs may be an efficient and cost-effective strategy for reducing HIV incidence in the broader population of cisgender MSM.
Source: Scientific Reports
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $1,870
Awards: G3014408768, G3624552299, Addressing psychosocial comorbidities in HIV treatment and prevention, Leveraging Social Networks to Improve Uptake of a Novel Biomedical HIV Prevention Method, G543839472, THE ROLE OF PROGESTERONE IN MALE PHENOTYPE EXPRESSION, Optimizing PrEP uptake & Adherence among MSWs using a 2-stage randomization design, G6996860927, HIV Risk for MSM Sex Workers: A Social, Sexual, & Drug Network Simulation Study, Enhancing Population Impact of HIV Pre-Exposure Prophylaxis Implementation, G7813237452, Highly Adaptive Epidemic Control Strategies for HIV Prevention in Drug Users, Los Angeles CRS for the MACS/WIHS Combined Cohort Study, Brown University Community and Clinical Research Training Program
OpenAlex ID: W3013236133