Work

Efficacy of Low-Dose Aripiprazole for Treatment of Psychotic Symptoms in a Patient with 22q11.2 Deletion Syndrome

Year: 2025

Type: article

Abstract: Objectives: The 22q11.2 deletion syndrome is one of the most prevalent genetic disorders and children suffering from this syndrome have been found to have a substantially greater risk for the development of schizophrenia and bipolar disorder. Psychiatric medications such as antipsychotics are commonly used in individuals with 22q11.2DS. Experimental Design: This is a case of 13 years male young man suffering from 22q11.2 deletion syndrome. Since adolescence, he presented with behavioural disorders, aggression, verbal abuse, sleep disorders. Principal Observations: The psychiatric examination confirmed the delusional idea, which was repeated in an obsessive way. There were also auditory hallucinations along with reference ideas. Aripiprazole was administered in 8 mg daily which gave more spectacular results and was better tolerated. Conclusions: In the present situation delusional ideas are no longer mentioned, but a cognitive deduction is found. Aripiprazole can be an effective pharmacological solution for the psychotic symptoms in patients suffering from 22q11DS.

Source: Psychopharmacology Bulletin

DOI: 10.64719/pb.4600

Authors: Konstantinos Kontoangelos, Eleni Lazaratou, Marina Economou, Konstantina G. Yiannopoulou, Charalambos C. Papageorgiou

Institutions: National and Kapodistrian University of Athens, University Mental Health Research Institute, Eginition Hospital, Henry Dunant Hospital

Language: English

Topic: Schizophrenia research and treatment

Subfield: Psychiatry and Mental health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W3013347755

FWCI: 0.632

Cites: 15

Cited by: 3

Related to: 20