Work

Cyanine dye mediated mitochondrial targeting enhances the anti-cancer activity of small-molecule cargoes

Year: 2020

Type: article

Abstract: Organelle-specific delivery systems are of significant clinical interest. We demonstrate the use of common cyanine dyes Cy3 and Cy5 as vectors for targeting and delivering cargoes to mitochondria in cancer cells. Specifically, conjugation to the dyes can increase cytotoxicity by up to 1000-fold.

Source: Chemical Communications

DOI: 10.1039/c9cc07931a

Authors: Alexander R. Nödling, Emily M. Mills, Xuefei Li, Davide Cardella, Edward J. Sayers, Shih-Hsiung Wu, Arwyn T. Jones, Louis Y. P. Luk, Yu-Hsuan Tsai

Institutions: Cardiff University, National Taiwan University, Institute of Biological Chemistry, Academia Sinica, Academia Sinica

Language: English

Topic: Nanoplatforms for cancer theranostics

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: Wellcome Trust, Tenovus, Cardiff University, Engineering and Physical Sciences Research Council, European Social Fund

Awards: G4730486603, Dihydrofolate reductase interactome: an unrecognised network that can control DNA synthesis and cell replication

OpenAlex ID: W3013373113

FWCI: 2.733

Cites: 44

Cited by: 58

Related to: 10