Renal Consequences of Cadmium Exposure Among Pregnant Women in Dhaka, Bangladesh Receiving Placebo or Vitamin D Supplementation: An Observational Cohort Study Nested within a Randomized Controlled Trial
Year: 2019
Type: dissertation
Abstract: Bangladeshi women are exposed to the toxic metal cadmium (Cd) through consumption of contaminated foods, and exposure to tobacco products. At high levels of vitamin D supplementation, increasing gastrointestinal uptake of Cd may occur. Cd exposure could lead to renal dysfunction, especially during a sensitive period such as pregnancy. In a cohort of pregnant Bangladeshi women enrolled in a randomized placebo-controlled trial of vitamin D supplementation in Dhaka, we examined the effect of vitamin D supplementation on maternal blood and cord blood Cd concentrations and the association of Cd with renal biomarkers. There was no effect of vitamin D supplementation on maternal blood Cd concentrations at delivery; however, vitamin D supplementation increased the probability of detecting Cd in cord blood. Maternal blood Cd concentrations were not associated with markers of renal functioning. Further work is required to clarify the potential effect of vitamin D on maternal-fetal transfer of Cd.
Source: TSpace (University of Toronto)
Author: Anna Zuchniak
Language: English
Subfield: Health, Toxicology and Mutagenesis
Field: Environmental Science
Domain: Physical Sciences
Open Access status: green
OpenAlex ID: W3013435555