Work

Inflammasomes as Targets for Adjuvants

Year: 2020

Type: article

Abstract: Inflammasomes are an essential part of the innate immune system. They are necessary for the development of a healthy immune response against infectious diseases. Inflammasome activation leads to the secretion of pro-inflammatory cytokines such as IL-1β and IL-18, which stimulate the adaptive immune system. Inflammasomes activators can be used as adjuvants to provide and maintain the strength of the immune response. This review is focused on the mechanisms of action and the effects of adjuvants on inflammasomes. The therapeutic and prophylaxis significance of inflammasomes in infectious diseases is also discussed.

Source: Pathogens

DOI: 10.3390/pathogens9040252

Authors: Konstantin Ivanov, Ekaterina Garanina, Albert Rizvanov, Svetlana Khaiboullina

Institutions: Kazan Federal University, Russian Academy of Sciences, Institute of Bioorganic Chemistry, University of Nevada, Reno

Language: English

Topic: Inflammasome and immune disorders

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,584