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Distinguishing reactive inflammatory dermatoses from lymphoma: 2 cases of severe drug reactions to phenytoin/phenobarbital and rosuvastatin mimicking lymphoma

Year: 2020

Type: article

Abstract: Cutaneous pseudolymphomas (CPL) are benign lymphoproliferative processes secondary to factors such as drug and arthropod reactions, infections, and inflammatory dermatoses that clinically and histologically mimic lymphoma.1,2 Similarly, severe cases of drug rash with eosinophilia and systemic symptoms (DRESS) syndrome or drug-induced hypersensitivity syndrome (DIHS) are reported to mimic systemic lymphoma due to blood count abnormalities, lymphadenopathy, and atypical peripheral blood smears. Although challenging at times, distinguishing lymphoma from CPL or a severe drug reaction is critical to avoid potentially unnecessary treatment and assign an appropriate favorable prognosis.

Source: JAAD Case Reports

DOI: 10.1016/j.jdcr.2020.01.016

Authors: Taylor Novice, Ji Won Ahn, Ryan Wilcox, Trilokraj Tejasvi, Alexandra Hristov, Jennifer Mancuso

Institution: University of Michigan

Language: English

Topic: Drug-Induced Adverse Reactions

Subfield: Pharmacology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $600