A Prospective Study of Acute Blood‐Based Biomarkers for Sport‐Related Concussion
Year: 2020
Type: article
Study design: Observational Study
Abstract: OBJECTIVE: Prospectively characterize changes in serum proteins following sport-related concussion and determine whether candidate biomarkers discriminate concussed athletes from controls and are associated with duration of symptoms following concussion. METHODS: High school and collegiate athletes were enrolled between 2015 and 2018. Blood was collected at preinjury baseline and within 6 hours (early acute) and at 24 to 48 hours (late acute) following concussion in football players (n = 106), matched uninjured football players (n = 84), and non-contact-sport athletes (n = 50). Glial fibrillary acidic protein, ubiquitin c-terminal hydrolase-L1, S100 calcium binding protein B, alpha-II-spectrin breakdown product 150, interleukin 6, interleukin 1 receptor antagonist, and c-reactive protein were measured in serum. Linear models assessed changes in protein concentrations over time. Receiver operating curves quantified the discrimination of concussed athletes from controls. A Cox proportional hazard model determined whether proteins were associated with symptom recovery. RESULTS: All proteins except glial fibrillary acidic protein and c-reactive protein were significantly elevated at the early acute phase postinjury relative to baseline and both control groups and discriminated concussed athletes from controls with areas under the curve of 0.68 to 0.84. The candidate biomarkers also significantly improved the discrimination of concussed athletes from noncontact controls compared to symptom severity alone. Glial fibrillary acidic protein was elevated postinjury relative to baseline in concussed athletes with a loss of consciousness or amnesia. Finally, early acute levels of interleukin 1 receptor antagonist were associated with the number of days to symptom recovery. INTERPRETATION: Brain injury and inflammatory proteins show promise as objective diagnostic biomarkers for sport-related concussion, and inflammatory markers may provide prognostic value. ANN NEUROL 2020;87:907-920.
Source: Annals of Neurology
DOI: 10.1002/ana.25725
Institutions: Medical College of Wisconsin, Marquette University, Laureate Institute for Brain Research, University of Tulsa, University of Oklahoma - Tulsa, Oklahoma State University Center for Health Sciences, University of Oklahoma, University of Rochester Medicine, University of Rochester, Banyan Biomarkers (United States)
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: Acute modulation of neural circuitry regulating immune function in depression, The role of neuroactive kynurenine metabolites in the chronic sequelae of concussion and contact sport exposure, COMPREHENSIVE STUDY OF ACUTE EFFECTS AND RECOVERY AFTER CONCUSSION, Inflammation and Kynurenine Metabolites in the Acute Sequelae of Concussion, Clinical and Translational Science Award, The Center for Neuroscience-based Mental Health Assessment and Prediction (NeuroMAP)
OpenAlex ID: W3013662321