Work

Hedgehog signaling pathway regulates liver regeneration in the Fah-/- knockout mice model xenografted by human hepatocytes.

Year: 2017

Type: article

Abstract: BACKGROUND: Nod/Scid mice model and plays a role in regulating liver regeneration after functional human hepatocytes xenograft. METHODS: . Hh signaling pathway associated factors were detected by RT-PCR and western blot. All statistical calculations were carried out using the SPSS.16.0 software. RESULTS: mice with HHT returned to normal. Hedgehog pathway activation and Hh-target genes were enhanced follows human hepatocytes transplantation which indicated liver regeneration associated closely with Hh signaling pathway. Moreover, Hh signaling was inhibited by cyclopamine after HHT. CONCLUSIONS: mice with HHT.

Source: PubMed

Authors: Xiaoqing Xu, Xiaohu Jiao, Yuhong Jiao, Min Wang, Chenwei Jiao

Institutions: Shandong University, Shandong Tumor Hospital, Shandong First Medical University, Xi'an Medical University, Shandong Provincial Hospital

Language: English

Topic: Liver physiology and pathology

Subfield: Hepatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W3013719925

FWCI: 0.153

Cites: 31

Cited by: 2

Related to: 10