Year: 2020
Type: review
Abstract: The traditional view of protein aggregation as being strictly disease-related has been challenged by many examples of cellular aggregates that regulate beneficial biological functions. When coupled with the emerging view that many regulatory proteins undergo phase separation to form dynamic cellular compartments, it has become clear that supramolecular assembly plays wide-ranging and critical roles in cellular regulation. This presents opportunities to develop new tools to probe and illuminate this biology, and to harness the unique properties of these self-assembling systems for synthetic biology for the purposeful manipulation of biological function.
Source: BMC Biology
Language: English
Subfield: Biomaterials
Field: Materials Science
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $2,990
Awards: Combatting antibiotic resistance with synthetic biology technologies, G1915869239, Collaborative Research: Evolvable Living Computing - Understanding and Quantifying Synthetic Biological Systems' Applicability, Performance, and Limits, CAREER: Evolution and Engineering of Cellular Bet-hedging Devices, G6671297155
OpenAlex ID: W3013752928