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The blood–brain barrier in health and disease: Important unanswered questions

Year: 2020

Type: article

Abstract: The blood vessels vascularizing the central nervous system exhibit a series of distinct properties that tightly control the movement of ions, molecules, and cells between the blood and the parenchyma. This "blood-brain barrier" is initiated during angiogenesis via signals from the surrounding neural environment, and its integrity remains vital for homeostasis and neural protection throughout life. Blood-brain barrier dysfunction contributes to pathology in a range of neurological conditions including multiple sclerosis, stroke, and epilepsy, and has also been implicated in neurodegenerative diseases such as Alzheimer's disease. This review will discuss current knowledge and key unanswered questions regarding the blood-brain barrier in health and disease.

Source: The Journal of Experimental Medicine

DOI: 10.1084/jem.20190062

Authors: Caterina P. Profaci, Roeben N. Munji, Robert S. Pulido, Richard Daneman

Institution: University of California San Diego

Language: English

Topic: Barrier Structure and Function Studies

Subfield: Neurology

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W3013784088

FWCI: 29.6

Cites: 238

Cited by: 762

Related to: 10