Work

DUSP6 SUMOylation protects cells from oxidative damage via direct regulation of Drp1 dephosphorylation

Year: 2020

Type: article

Abstract: mutant, protected cells from apoptosis. Thus, DUSP6 exerts a cytoprotective role by directly dephosphorylating Drp1-S616, which is disrupted by deSUMOylation under oxidation.

Source: Science Advances

DOI: 10.1126/sciadv.aaz0361

Authors: Ruining Ma, Lina Ma, Weiji Weng, Yingping Wang, Huiqing Liu, Rongjun Guo, Yingwei Gao, Jun Tu, Tian-Le Xu, Jinke Cheng, Michael X. Zhu, Aiwu Zhou, Yong Li

Institutions: Shanghai Jiao Tong University, The University of Texas Health Science Center at Houston

Language: English

Topic: Mitochondrial Function and Pathology

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $4,500

Funder: National Natural Science Foundation of China

Awards: SUMO/deSUMO修饰在痛痒觉调控中的作用和机制, G577295891

OpenAlex ID: W3013785324

FWCI: 3.042

Cites: 61

Cited by: 90

Related to: 10