Potential gains in life expectancy from reducing amenable mortality among people diagnosed with serious mental illness in the United Kingdom
Year: 2020
Type: article
Abstract: BACKGROUND: To estimate the potential gain in life expectancy from addressing modifiable risk factors for all-cause mortality (excluding suicide and deaths from accidents or violence) across specific serious mental illness (SMI) subgroups, namely schizophrenia, schizoaffective disorders, and bipolar disorders in a Western population. METHODS: We have used relative risks from recent meta-analyses to estimate the population attribution fraction (PAF) due to specific modifiable risk factors known to be associated with all-cause mortality within SMI. The potential gain in life expectancy at birth, age 50 and age 65 years were assessed by estimating the combined effect of modifiable risk factors from different contextual levels (behavioural, healthcare, social) and accounting for the effectiveness of existing interventions tackling these factors. Projections for annual gain in life expectancy at birth during a two-decade was estimated using the Annual Percentage Change (APC) formula. The predicted estimates were based on mortality rates for year 2014-2015. RESULTS: Based on the effectiveness of existing interventions targeting these modifiable risk factors, we estimated potential gain in life expectancy at birth of four (bipolar disorders), six (schizoaffective disorders), or seven years (schizophrenia). The gain in life expectancy at age 50 years was three (bipolar disorders) or five (schizophrenia and schizoaffective disorders) years. The projected gain in life expectancy at age 65 years was three (bipolar disorders) or four (schizophrenia and schizoaffective disorders) years. CONCLUSIONS: The implementation of existing interventions targeting modifiable risk factors could narrow the current mortality gap between the general and the SMI populations by 24% (men) to 28% (women). These projections represent ideal circumstances and without the limitation of overestimation which often comes with PAFs.
Source: PLoS ONE
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $1,695
Funders: Eli Lilly and Company, Biogen, Stanley Medical Research Institute, South London and Maudsley NHS Foundation Trust, Sunovion, King's College Hospital NHS Foundation Trust, Maudsley Charity, European Federation of Pharmaceutical Industries and Associations, National Institute for Health and Care Research, Department of Health and Social Care, King's College London, Innovative Medicines Initiative, H. Lundbeck A/S, Medical Research Council, Engineering and Physical Sciences Research Council, National Institute for Health Research Applied Research Collaboration South London
Awards: NIHR Senior Investigator Award, NIHR Senior Investigator Award, Healtex: UK Healthcare Text Analytics Research Network, KCL Application for a Mental Health Data Pathfinder award, Violence, Health and Society, NIHR Senior Investigator Award, Mechanisms and consequences of depression-related multimorbidity over the life course: coordinated analysis of population and primary care data
OpenAlex ID: W3013958660