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Selective covalent targeting of GPX4 using masked nitrile-oxide electrophiles

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Year: 2020
Type: article
Source: Nature Chemical Biology
DOI: 10.1038/s41589-020-0501-5
Authors: John K. Eaton, Laura Furst, Richard A. Ruberto, Dieter Moosmayer, André Hilpmann, Matthew J. Ryan, Katja Zimmermann, Luke L. Cai, Michael Niehues, Volker Badock, Anneke Kramm, Sixun Chen, Roman C. Hillig, Paul A. Clemons, Stefan Gradl, Claire Montagnon, Kiel E. Lazarski, Sven Christian, Besnik Bajrami, Roland Neuhaus, Ashley L. Eheim, Vasanthi S. Viswanathan, Stuart L. Schreiber
Institutions: Broad Institute, Bayer (Germany), Harvard University
Language: English

Topic: Ferroptosis and cancer prognosis
Subfield: Cancer Research
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
SDG: Good health and well-being

Open Access status: green

Funders: U.S. Department of Health and Human Services, Bayer, Broad Institute, National Institutes of Health, National Institute of General Medical Sciences
Awards: Studies of Materials with Physiological Properties, Studies of Materials with Physiological Properties, G4115543777
OpenAlex ID: W3014091199
FWCI: 16.82
Cites: 93
Cited by: 535
Related to: 10
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