Work

Translation-Targeting RiPPs and Where to Find Them

Year: 2020

Type: review

Abstract: Prokaryotic translation is among the major targets of diverse natural products with antibacterial activity including several classes of clinically relevant antibiotics. In this review, we summarize the information about the structure, biosynthesis, and modes of action of translation inhibiting ribosomally synthesized and post-translationally modified peptides (RiPPs). Azol(in)e-containing RiPPs are known to target translation, and several new compounds inhibiting the ribosome have been characterized recently. We performed a systematic search for biosynthetic gene clusters (BGCs) of azol(in)e-containing RiPPs. This search uncovered several groups of clusters that likely direct the synthesis of novel compounds, some of which may be targeting the ribosome.

Source: Frontiers in Genetics

DOI: 10.3389/fgene.2020.00226

Authors: Dmitrii Y. Travin, Dmitry Bikmetov, Konstantin Severinov

Institutions: Skolkovo Institute of Science and Technology, Russian Academy of Sciences, Institute of Gene Biology, Institute of Molecular Genetics, Rutgers, The State University of New Jersey

Language: English

Topic: Microbial Natural Products and Biosynthesis

Subfield: Applied Microbiology and Biotechnology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,950