Work

Copper(I)-Mediated 11C-Carboxylation of (Hetero)arylstannanes

Year: 2020

Type: article

Abstract: A novel copper-mediated carboxylation strategy of aryl- and heteroaryl-stannanes is described. The method serves as a mild (i.e., 1 atm) carboxylation method using stable carbon dioxide and is transferable as a radiosynthetic approach for carbon-11-labeled aromatic and heteroaromatic carboxylic acids using sub-stoichiometric quantities of [11C]CO2. The methodology was applied to the radiosynthesis of the retinoid X receptor agonist, [11C]bexarotene, with a decay-corrected radiochemical yield of 32 ± 5% and molar activity of 38 ± 23 GBq/μmol (n = 3).

Source: ACS Omega

DOI: 10.1021/acsomega.0c00524

Authors: Ian R. Duffy, Neil Vasdev, Kenneth Dahl

Institutions: Centre for Addiction and Mental Health, University of Toronto

Language: English

Topic: Radiopharmaceutical Chemistry and Applications

Subfield: Radiology, Nuclear Medicine and Imaging

Field: Medicine

Domain: Health Sciences

Open Access status: gold

Estimated APC paid: $750