Clinical and pathological findings of surgically resected patients for lung adenocarcinomas harboring uncommon EGFR mutations.
Year: 2017
Type: article
Study design: Observational Study
Abstract: BACKGROUND: This study aimed to examine the clinical and pathological characteristics of surgically resected lung adenocarcinoma patients harboring uncommon epidermal growth factor receptor (EGFR) mutations and provide a rational basis to provide postoperative adjuvant treatment for these patients. METHODS: Data from 13 patients with lung adenocarcinomas harboring uncommon EGFR mutations were retrospectively collected, and the clinicopathological parameters and disease-free survival (DFS) data analyzed. RESULTS: EGFR uncommon mutations commonly occurred in acinar predominant adenocarcinomas, females, and never smokers. Despite treatment, six patients relapsed. CONCLUSION: Patients with EGFR 20 insertion mutations relapsed quickly. Postoperative adjuvant treatment with chemotherapeutic drugs or new tyrosine kinase inhibitors for lung adenocarcinoma patients harboring EGFR 20 insertion mutations requires further evaluation.
Source: PubMed
Authors: Shifeng Yang, Zhiming Jiang, Hongyang Lu
Institution: Zhejiang Cancer Hospital
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W3014162859