Year: 2020
Type: article
Abstract: As biochemical systems may frequently suffer from limited energy resources, so that internal molecular fluctuation has to be utilized to induce random rhythm, it is still a great theoretical challenge to understand the elementary principles for biochemical systems with limited energy resources to maintain phase accuracy and phase sensitivity.Here, we address the issue by deriving the energy-accuracy and the sensitivity-accuracy trade-off relations for a general biochemical model, analytically and numerically.We find that biochemical systems have a much lower energy cost by using noise-induced oscillations to keep almost equal efficiency to maintain precise processes compared with the energy cost using normal oscillations, clearly elucidating a survival mechanism when energy resources are limited.Moreover, an optimal system size is predicted where both the highest sensitivity and highest accuracy can be reached at the same time, providing a new strategy for the design of biological networks with limited energy sources.
Source: Physical Review Research
Authors: Zhiyu Cao, Huijun Jiang, Zhonghuai Hou
Institution: University of Science and Technology of China
Language: English
Subfield: Statistical and Nonlinear Physics
Field: Physics and Astronomy
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $2,625
OpenAlex ID: W3014173346