Plasma Cell Fate Is Orchestrated by Elaborate Changes in Genome Compartmentalization and Inter-chromosomal Hubs
Year: 2020
Type: article
Abstract: (Cell Reports 31, 107470-1–107470-15.e1–e6; April 7, 2020) In the originally published version of this article, the description of results presented in Figure 4B was incorrect. In the text, we referred incorrectly to Bcl6 rather than Prdm1. The Figure 4B legend contained the same error. The errors have been corrected and now appear with the article online. The authors regret this error. Plasma Cell Fate Is Orchestrated by Elaborate Changes in Genome Compartmentalization and Inter-chromosomal HubsBortnick et al.Cell ReportsApril 07, 2020In BriefBortnick et al. demonstrate that plasma cell fate is associated with changes in chromatin folding, inter-chromosomal interactions, and nuclear localization involving plasma-cell-specific genes. Inter-chromosomal hubs in maturing B cells are enriched for the deposition of either H3K27Ac or H3K27me3. We propose that deposition of these marks facilitates inter-chromosomal interactions. Full-Text PDF Open Access
Source: Cell Reports
Authors: Alexandra Bortnick, Zhaoren He, Megan Aubrey, Vivek Chandra, Matthew Denholtz, Kenian Chen, Yin C. Lin, Cornelis Murre
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $5,200
OpenAlex ID: W3014227429