Work

Comparison of proinsulin to C-peptide ratio in children with and without type 1 diabetes and its relation to age

Year: 2020

Type: article

Abstract: PURPOSE: This study aimed to compare the proinsulin to C-peptide (PI:C) ratio in those with recent-onset type 1 diabetes versus those with no diabetes and to explore the effect of age on PI:C ratio. METHODS: Nineteen participants (n=9 with type 1 diabetes and n=10 with no diabetes) between 10 and 19 years of age were enrolled in a single-visit cross-sectional study and underwent blood collection after 10 hours fasting to measure proinsulin and C-peptide levels as well as other glycemic parameters. RESULTS: The median PI:C ratio was significantly different between type 1 diabetes and nondiabetes groups (6.24% vs. 1.46%, P<0.01). A significant negative correlation was seen between PI:C ratio and patient age after adjustment for duration of diabetes (r2=0.61, P=0.02) in the type 1 diabetes group. CONCLUSION: Even in this narrow age window, a higher degree of β-cell dysfunction indicated by a higher PI:C ratio was seen in younger children.

Source: Annals of Pediatric Endocrinology & Metabolism

DOI: 10.6065/apem.2020.25.1.38

Authors: Benjamin R. Ellison, Jeffrey H. Burton, Daniel S. Hsia

Institutions: Baylor University, Pennington Biomedical Research Center

Language: English

Topic: Diabetes and associated disorders

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

Funders: Pennington Biomedical Research Foundation, Louisiana Clinical and Translational Science Center, National Institute of General Medical Sciences