The association and joint effect of serum cholesterol, glycemic status with the risk of incident cancer among middle-aged and elderly population in china cardiometabolic disease and cancer cohort (4C)-study.
Year: 2020
Type: article
Study design: Observational Study
Abstract: The associations between different combinations of metabolic abnormalities and the risk of all and site-specific cancers remain unclear. We aimed to estimate the association and interplay between serum cholesterol, glycemic status and risk of cancer in the China Cardiometabolic Disease and Cancer Cohort (4C)-Study, a nationwide, multicenter, prospective, population-based study. The investigation was performed in 137,884 participants during 2014-2016. Incident cancer was defined as the first occurrence of any type cancer of all sites during follow-up. After 510,164 person-years of follow-up, 1,710 were detected as incident cancer after exclusion of participants diagnosed as cancer within 6 months from baseline. A relatively low level of LDL cholesterol (<100 mg/dl) was related to a significant higher risk of incident cancer [1.20 (1.08-1.34); P=0.0007]. Diabetic individuals have a significantly higher risk of incident cancer, especially those with poorly glycemic control. Diabetic participants with both lower levels of LDL cholesterol and poorly glycemic control were at a higher risk of incident cancer [1.42 (1.10-1.81); P=0.006]. Our study showed a positive association of cancer risk with low-level LDL cholesterol and diabetes and found that participants with both lower levels of LDL cholesterol and poorly controlled diabetes had the higher risk of incident cancer, which indicates the compelling need of achieving glycemic control goal and maintaining appropriate LDL cholesterol levels.
Source: PubMed
Authors: Mian Li, Jieli Lu, Jing Fu, Qin Wan, Tiange Wang, Yanan Huo, Yu Xu, Min Xu, Zhiyun Zhao, Yuhong Chen, Shuangyuan Wang, Guijun Qin, Yingfen Qin, Ruying Hu, Xulei Tang, Guixia Wang, Feixia Shen, Zuojie Luo, Li Chen, Qing Su, Xuefeng Yu, Li Yan, Gang Chen, Zhengnan Gao, Yinfei Zhang, Chao Liu, Youmin Wang, Shengli Wu, Tao Yang, Qiang Li, Yiming Mu, Jiajun Zhao, Lulu Chen, Lixin Shi, Guang Ning, Yufang Bi, Hongyang Wang, Weiqing Wang
Institutions: Shanghai Jiao Tong University, Ruijin Hospital, State Key Laboratory of Medical Genomics, Second Military Medical University, Eastern Hepatobiliary Surgery Hospital, Southwest Medical University, Affiliated Hospital of Southwest Medical University, Nanchang University, Jiangxi Provincial People's Hospital, First Affiliated Hospital of Zhengzhou University, First Affiliated Hospital of GuangXi Medical University, Zhejiang Center for Disease Control and Prevention, First Hospital of Lanzhou University, First Hospital of Jilin University, First Affiliated Hospital of Wenzhou Medical University, Qilu Hospital of Shandong University, XinHua Hospital, Tongji Hospital, Huazhong University of Science and Technology, Sun Yat-sen University, Sun Yat-sen Memorial Hospital, Fujian Medical University, Fujian Provincial Hospital, Dalian Municipal Central Hospital, Jiading District Central Hospital, Jiangsu Province Hospital, First Affiliated Hospital of Anhui Medical University, Second Affiliated Hospital of Harbin Medical University, Chinese People's Liberation Army, Shandong University, Shandong Provincial Hospital, Wuhan Union Hospital, Guiyang Medical University
Language: English
Topic: Cancer Risks and Factors
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W3014259098