Work

Rationally Designed Small-Molecule Inhibitors Targeting an Unconventional Pocket on the TLR8 Protein–Protein Interface

Year: 2020

Type: article

Source: Journal of Medicinal Chemistry

DOI: 10.1021/acs.jmedchem.9b02128

Authors: Shuangshuang Jiang, Hiromi Tanji, Kejun Yin, Shuting Zhang, Kentaro Sakaniwa, Jian Huang, Yi Yang, Jing Li, Umeharu Ohto, Toshiyuki Shimizu, Hang Yin

Institutions: Peking University, Center for Life Sciences, Tsinghua University, The University of Tokyo, Chinese Academy of Medical Sciences & Peking Union Medical College, Peking Union Medical College Hospital

Language: English

Topic: Immune Response and Inflammation

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: closed

Funders: Japan Agency for Medical Research and Development, Ministry of Education, Culture, Sports, Science and Technology, National Natural Science Foundation of China, Ministry of Education of the People's Republic of China, Japan Society for the Promotion of Science, Core Research for Evolutional Science and Technology

Awards: G1612314718, 靶向Toll样受体8的小分子抑制的设计合成、生物学评价及作用机制研究, G2936721283, 構造生物学的手法を用いた、自然免疫受容体TLRのシグナル伝達機構の解明, G5935722757, G6076798619, Elucidation of a complete picture of the activation mechanism of Toll-like receptors in lipid bilayers by multilevel analysis, G7570462418, G7773460874, G791393332, G8015106359

OpenAlex ID: W3014370465

FWCI: 1.835

Cites: 37

Cited by: 28

Related to: 10